Salmon DNA mesotherapy is the application of a polynucleotide (PN) product into the skin through micro-injections to support the skin's own capacity for renewal. In the medical literature it is also referred to as "polynucleotide therapy" or "PN/PDRN injection".
Polynucleotides are chains made of nucleotides, the building blocks of DNA. The PN in these products is produced by purifying DNA obtained from salmon reproductive cells; after purification, almost no fish protein remains.
Polynucleotide mesotherapy is not a filler: it does not add volume or change facial contours. Its aim is to improve skin quality – hydration, elasticity, texture and radiance – from within. For this reason it is classed as a "skin rejuvenator" or "skin booster".
Although the mechanism of action is still being studied, three pathways stand out in the scientific literature:
Because lasting improvement depends on collagen production, it appears gradually over several weeks.
A common question: Salmon DNA does not mix with human DNA or change your genetic make-up. The body uses these molecules as building blocks and signalling molecules.
How it differs from creams: Polynucleotide molecules are too large to pass through intact skin. Creams containing "salmon DNA" work as moisturisers; they do not provide the effect achieved by injection.
Polynucleotide products are prepared in different concentrations depending on the area and need. The doctor decides which form to use after the examination.
| Form | Characteristics | Area of use |
|---|---|---|
| Standard (medium concentration) | PN only | Full face: hydration, elasticity, skin texture, fine lines |
| With hyaluronic acid | Lower PN + hyaluronic acid + local anaesthetic | Less painful treatment, extra hydration needs |
| Low concentration | Fluid consistency suited to thin tissue | Thin skin around the eyes, crow's feet |
| High concentration | Thicker consistency | Depressed acne scars and scars |
Improving skin quality on the face, neck and décolletage
Fine lines and thin skin around the eyes
Acne scars and enlarged pores
Dry-prone, sensitive or barrier-weakened skin
Combination treatment with procedures such as laser and peels
The skin is assessed, allergies (especially fish allergy) and medical history are reviewed, and the appropriate product is chosen.
Make-up is removed and a numbing cream is applied.
The product is delivered into the superficial layer of the skin with a fine needle or cannula through micro-injections. The procedure takes about 20–30 minutes.
The area is cooled and aftercare advice is given.
Number of sessions: Usually 3 sessions 2–4 weeks apart are recommended; acne scars may need 3–5 sessions. 1–2 sessions a year can be repeated to maintain the effect. Results appear gradually, becoming noticeable within the first 3–6 months.
Before treatment: Unless your doctor advises otherwise, avoid anti-inflammatory painkillers (NSAIDs), fish oil supplements and alcohol for a few days beforehand.
After treatment:
Published clinical data show a low risk of serious side effects when performed by an experienced physician; however, long-term safety data are still limited.
Infection, allergic reaction, prolonged swelling or nodules. If anything unusual occurs, contact our clinic immediately.
No. It does not add volume or change the shape of the face; it aims to improve skin quality.
A numbing cream is used. For people sensitive to pain, forms containing an anaesthetic may be preferred.
Hydration and radiance may be noticeable in the first weeks. Improvement in texture and elasticity becomes clearer over a few months as the sessions progress.
It varies from person to person. After the course, the effect can be supported with 1–2 sessions a year.
Yes. Bumps at the injection points may be visible for 1–3 days; make-up can be applied the next day.
No. The product does not mix with human DNA; the body uses these molecules as building blocks.
Following a doctor's assessment, it can be combined in a planned way with laser, peels and other skin rejuvenation treatments.
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